I just got my upgrade to Zbrush 4R6 and was anxious to try the new ZRemesher plug in. WOW! It really is a game changer. I used the default settings on the latest character and within 2 minutes it had done a pretty impressive job. It needs some refinements as it's not 100 percent spot on, but it's really close. My original sculpt had 1.8 million polygons. It's now down to 18,000. With a little tweaking, this could be a fully animatable mesh! Kudos to Pixologic for an awesome fabulous update!